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Title   췌장침범등 국소진행을 보이는 위암환자에서 유도약물요법의 효과 ( Induction Chemotherapy and Surgery in Locally Advanced Stomach Cancer Showing Pancreas Involvement )
Publicationinfo   1994 Jan; 026(03): 377-385.
Key_word   Stomach cancer, Locally advanced, Induction chemotherapy
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Abstract   Gastric cancer is the most common malignancy in Korea. Cure for patients with gastric carcinoma can be achieved only by radical surgery. From August 1988 to May 1992, 25 patients with locally advanced unresectable gastric cancer received 5-FU(Fiuorouracil) + adriamydn + mitomycin-c or 5-FU + cisplatin based induction chemotherapy before surgem. The partial response rate after me- dian 3 cycles of induction cemotherapy was 52%, stable disease 12%, progressive disease 36%. Gastric resection was performed in 18 patients(72%); 13 patients(52%) underwent radical surgery and 5 patients(20%) underwent palliative surgery. Median survival of the patients who underwent cura- tive and palliative surgery was 24. 2 and 27 months, respectively. However, median survival of the patient who didnt undergo any surgery was only 6.5 months. The difference of median survival between curative surgery and none surgery group were significant statistically(P<0.03). Side effects of induction chemotherapy were acceptable and there were no life threatening toxicities In this study, half of the patients can undergo curative surgery after induction chemotherapy. We observe the long term survival in some patients after induction chemotherapy and surgery in loco-regionally advanced gsstric cancer. This therapeutic approch for the locally advanced stomach cancer seems to be feasible. But, prospective tandomized clinical trial is warranted in the future.
저 자   이경희(Kyung Hee Lee),최진혁(Jin Hyuk Choi),라선영(Sun Young Rha),이혜란(Hye Ran Lee),유내춘(Nae Chun Yoo),임호영(Ho Yeong Lim),정현철(Hyun Cheol Chung),김주항(Joo Hang Kim),노재경(Jae Kyung Roh),김병수(Byung Soo Kim)